Abstract: Nonalcoholic fatty liver disease (NAFLD) is a complex acquired liver injury disease caused by metabolic stress. The occurrence and development of NAFLD are affected by genetics, aging, lifestyle, diet, central obesity-related insulin resistance, metabolic syndrome, and intestinal flora. Recently, increasing attention has been focused on the role of intestinal flora in NAFLD pathogenesis. Intestinal flora has significant effects on liver functions through multiple physiological processes, including energy metabolism, obesity, type II diabetes, and NAFLD. Animal experiments provide strong evidence that an intestinal flora imbalance plays a major role in the occurrence and development of obesity and NAFLD. Here, we discuss the application of laboratory animals in the study of intestinal flora and NAFLD.

Key words: laboratory animal, intestinal flora, nonalcoholic fatty liver disease

摘要： 非酒精性脂肪肝病(NAFLD)是一种复杂的获得性代谢应激肝损伤疾病,NAFLD 的发生发展受遗传、老龄化、生活方式、饮食、中心性肥胖相关的胰岛素抵抗、代谢综合征以及肠道菌群等相关联的并行因素的影响。 近年来,人们越来越重视肠道菌群在 NAFLD 发病机制中的作用。 肠道菌群通过多个生理过程对体内肝功能有显著影响,包括能量代谢、肥胖、糖尿病和 NAFLD。 动物实验提供了有力的证据,表明肠道菌群失调在肥胖症和 NAFLD 疾病发生发展中发挥了重要作用。 本文对实验动物在肠道菌群与非酒精性脂肪肝病研究中的应用进行探讨。

关键词: 实验动物, 肠道菌群, 非酒精性脂肪肝病